| abstract |
1. A process for the preparation of a carbostyril derivative, represented by the general formula: **(Formula)** where R1 is a hydrogen atom, an alkyl group having from 1 to 6 carbon atoms, a alkenyl having 2 to 4 carbon atoms, an alkynyl group having 2 to 4 carbon atoms, or a phenylalkyl group having an alkylene group of 1 to 4 carbon atoms or a phenyl group; R4 is a hydrogen atom, or an alkyl group having 1 to 4 carbon atoms; R5 is a cycloalkyl group having 3 to 8 carbon atoms, a phenyl group which may have 1 to 3 substituent groups selected from the group consisting of halogen atoms, alkyl groups having 1 to 4 carbon atoms, and alkoxy groups having 1 to 4 carbon atoms, a substituted alkyl group having 1 to 4 carbon atoms, the substituent being a hydroxyl group, a phenyl group or an alkanoyloxy group having 1 to 4 carbon atoms, an alkanoyl group having 1 to 4 carbon atoms or a benzoyl group; R6 is a hydrogen atom, a hydroxy group or an alkyl group of 1 to 4 carbon atoms, or a -OR7 group, where R7 is an alkanoyloxy group of 1 to 4 carbon atoms, or a 3,4,5 group trimethoxybenzoyl; q is an integer of 2 or 3; l and m are respectively 0 or an integer from 1 to 6, but the sum of l and m must not exceed 6; X is a halogen atom; n is 0 or an integer of 1 or 2; the carbon-carbon bond between the 3- and 4-positions of the carbostyril skeleton is a single or double bond. |