| abstract |
New alpha, w-disubstituted polymethylene compounds with action on histamine receptors, to processes for their preparation, to pharmaceutical compositions containing them and to their use in therapeutics. It has now been found that certain new alpha, w-disubstituted polymethylene compounds possess potent activity as H2 antagonists. Compounds with H2 histamine blocking activity can be used in the treatment of conditions where gastric acid hypersecretion occurs, especially gastric and peptic ulcers, as a prophylactic measure in surgical procedures and in the treatment of allergic conditions. and inflammatory where histamine is a known mediator. |