http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-8106906-A1

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filingDate 1980-10-08^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 1981-09-16^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber ES-8106906-A1
titleOfInvention A PROCEDURE FOR THE PREPARATION OF A PENAM DERIVATIVE
abstract PROCEDURE FOR THE PREPARATION OF A "PENAM" DERIVATIVE OF FORMULA (I), R being PHENYL, P-HYDROXYPHENYL, P-ALKYL CARBONYLOXIPHENYL OR 2- O 3-THYENYL; R1 HYDROGEN OR A GROUP SUSCEPTIBLE TO FORMING A SALT OR A PHARMACEUTICALLY ACCEPTABLE ESTER, AND R2 HYDROGEN, OR A GROUP SUSCEPTIBLE TO FORMING A SALT OR HYDROLIZABLE ESTER "IN VIVO", PHARMACOLOGICALLY ACCEPTABLE. A COMPOUND OF FORMULA (II) IS REACTED AT A TEMPERATURE OF -20G TO 20GC, WHERE R ELEVATED AX IS A RADICAL THAT FORMS AN ESTER, R ELEVATED A AND IS HYDROGEN OR RADICAL THAT FORMS A SALT OR A BLOCKING GROUP OF CARBOXYL, AND R3 IT IS AN ARILO GROUP; WITH METHANOL, IN THE PRESENCE OF SILVER, THALIUM OR MERCURIC IONS, OR OF CHLORINE AND A BASE. OPTIONALLY, THE CARBOXYL BLOCKING GROUPS ARE ELIMINATED AND THE PRODUCT IS TREATED TO OBTAIN IT IN THE FORM OF SALT OR ESTER. OF APPLICATION AS A BACTERIAL AGENT. *FORMULA*
priorityDate 1979-10-09^^<http://www.w3.org/2001/XMLSchema#date>
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