http://rdf.ncbi.nlm.nih.gov/pubchem/patent/FI-89487-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_14effe3850d2129f863b969dac4f1db8 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 |
| filingDate | 1990-08-24^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1993-06-30^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_61f53f6938e9922a2b42d671732ab07a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_38bde68a9e1187868fe9a1a42e426f34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a96af35754d629eaf0d3e8adaec1bce0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ad5e8088079737f73c2110d274973dbf |
| publicationDate | 1993-06-30^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | FI-89487-B |
| titleOfInvention | For the preparation of therapeutically active 4 - [(substituted) alkylcarbonyl] -4,5-dihydro- and -4,5,6,7-tetrahydro-7 - [(substituted) phenyl] pyrazolo [1,5-a] pyrimidin-3-karbonitriler |
| abstract | The invention relates to a process for the preparation of therapeutically active 4-[(substituted)alkylcarbonyl]-4,5- dihydro and -4,5,6,7-tetrahydro-7-[(substituted)- phenyl]pyrazolo[1,5-a]pyrimidine-3-carbonitriles of the formula <IMAGE> wherein n is an integer from 1 to 4 inclusive; R7 is a mono- or disubstituent, which may be hydrogen, alkyl, alkoxy, halogen, nitro, N-alkyl-N-alkanoylamino, trifluoromethyl; R2 is cyano, carboxamido, ethyl carboxylate or halogen; Z is CH-, N- or -O- so that where Z is CH-, R10 is hydrogen, ethoxycarbonyl, phenyl, phenylmethyl or phenylmethylalkenyl; and where Z is -O-, R3 is absent and where Z is N-, R3 is alkyl, alkenyl, alkynyl, cycloalkyl, dimethylaminoalkyl, hydroxyalkyl, ethylcarboxylate, alkylcarbonyl, phenyl, benzyl, mono- or disubstituted benzyl, benzoyl, 4-chlorophenylmethyl, 1,3- benzodioxol-5-ylmethyl, 1,3-benzodioxol-5-yl, 2- furanylcarbonyl, 2-pyrimidinyl, 2-pyridinyl, 4- morpholinyl-2-oxoethyl, N-(1-methylethyl)-2-oxoethyl, 1- pyrrolidinyl-2-oxoethyl, bis(4-fluorophenyl)methyl, 2- cyclohexylethyl, phenylcarboxamido, mono- or disubstituted phenylcarboxamido, adamantanoyl, 3- phenoxypropyl, mono- and disubstituted phenyl, 5-chloro-2- methoxyphenylacetamide or (2-oxo-1-pyrrolidinyl)-2- butynyl;R4 and R5 are both hydrogen or alkyl; and for the preparation of pharmacologically acceptable acid addition salts thereof. |
| priorityDate | 1986-10-16^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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