http://rdf.ncbi.nlm.nih.gov/pubchem/patent/FR-2118081-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_620ecb9324409347c27e96b6071503ee |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D499-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D499-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D499-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-43 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-431 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D499-72 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D499-12 |
| filingDate | 1971-12-14^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1972-07-28^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | FR-2118081-A1 |
| titleOfInvention | Semi-synthetic penicillin prepn - from natural penicillins via the imino-ether |
| abstract | Title cpds. of formula (I) are prepd. by esterification of (II): (where RCO = an organoacyl gp.; R2 is an organic residue; R3 is H, alkali metal or a gp. which is easily removed in the blood stream; M is H or alkali metal), to protect the carboxyl gp. with a gp. which is chemically removed under gentle conditions which do not destroy the ring or is easily removable in the blood. This ester is reacted with a phosphorus halide in an inert solvent to give the imino-halide which is reacted with a lower alkanol to produce the imino-ether. The imino-ether is condensed with R2COOH or its active deriv. and this product treated with water or an alkanol with optional removal of the protecting ester gp. |
| priorityDate | 1970-12-14^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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