http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1071602-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2b8b744d430e252fa21c14c2b8dee176 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-552 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-55566 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N1-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-098 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/F16H61-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/F16H63-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/F16H59-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/F16H63-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/F16H63-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/F16H63-34 |
| filingDate | 1964-05-19^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1967-06-07^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1071602-A |
| titleOfInvention | Improvements in or relating to immunisation against brucella infections |
| abstract | Brucella abortus is grown in liquid culture in a conventional medium. The culture is preferably performed under submerged aerated conditions, using a freeze-dried preparation of the strain McEwan 45/20 rough as an inoculum. The culture procedure is similar to that of Specification No. 951,299 wherein the organism used is Strain 19 of Brucella abortus. The culture is used, after treatment to kill the bacteria, to prepare a vaccine.ALSO:Vaccines for immunising against Brucella infections are prepared by growing Brucella abortus organisms in a liquid culture medium, treating the organisms so that they are killed, and incorporating the dead organisms in an adjuvant vaccine with a vaccine oil and at least one emulsifying agent, the organisms being of a strain which, when killed can stimulate immunity without producing agglutinogenic activity. The vaccine preferably contains both a water-in-oil and an oil-in-water emulsifier, the latter comprising 2 to 10% by weight of the former, suitable emulsifiers being respectively mono-, di, or tri-oleate esters of mannide, sorbitan or mannitan or mixtures thereof; and polyoxyethylene derivatives of C12 to C20 fatty acid esters of polyhydric alcohols. The preferred organism is that of the strain McEwen 45/20 rough, which is grown in submerged aerated culture, and killed by heating, e.g. to 50 DEG to 75 DEG C., after which the organisms are centrifuged off, resuspended in water, and a preservative such as merthiolate being then optionally added. This preparation may then be used directly to prepare the vaccine, by homogenising it with the emulsifiers and the oil, the latter suitably being pharmaceutical grade liquid paraffin. The invention includes a method for immunising ruminants against Brucellosis by injection of the vaccine, preferably into the neck muscles. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/FR-2479000-A1 |
| priorityDate | 1963-05-21^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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