| abstract |
Described are compounds of Formula (1)or a pharmaceutically acceptable derivative, N-oxide, salt, hydrate, solvate, complex, bioisostere, metabolite or prodrug thereof, wherein Ar2, L2, Ar1, L1, Raa, R3, R5and Y are as defined therein, the compound being a dual calpain-ROS inhibitor for the treatment of a disease mediated by ROS and/or calpain hyperactivity. |