| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e6e69edd7628feea8e3deab3bf7fef43 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-502
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5025
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-501
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-513
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5025
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-513
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-501
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-502 |
| filingDate |
2014-07-16^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_59432516b22e5a7bd52197389edb926e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_12544851bd473ab0c186943d5c45adb0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6a65ac6b880ca5eaa80d54a129a33ab5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_157eb585e468a0df02b7e5e2dc31d1ba
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b175275eab26e0d49c6fafa79e26c9ff |
| publicationDate |
2016-01-20^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
GB-2528298-A |
| titleOfInvention |
Compounds |
| abstract |
(I) Compounds of formula (I) or a pharmaceutically acceptable salt or solvate thereof wherein R1, R2 and R3 are as herein defined; R4 is a substitutent as herein defined or both R4 groups form a ring together with the carbon atoms to which they are attached to form a fused bicyclic ring containing from 8 to 12 atoms which may be saturated or unsaturated provided that when R1 is a substituted or unsubstituted pyrazolyl then R4 is not H and where both adjacent R4 groups form a ring with the atoms to which they are attached the adjacent R4 groups do not form an unsaturated carbocyclic ring with 6 carbon atoms; when R1 is a substituted or unsubstituted C6-10aryl then R4 is not H or methyl and where both adjacent R4 groups form a ring with the atoms to which they are attached the adjacent R4 groups do not form an unsaturated carbocyclic ring with 6 carbon atoms; and when R1 is a substituted or unsubstituted pyridyl then R4 is not methyl. The compound 4-fluoro-N-[[1-[4-(2-methylpyrazol-3-yl)phthalazin-1-yl]pyrrolidin-3-yl]methyl]-2-(trifluoromethyl)benzamide is also provided. The compounds of formula (I) are useful as inhibitors in the hedgehog signalling pathway, particularly Smoothened (Smo) in the treatment of cancer. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022095953-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106279114-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106279114-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107163028-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022090711-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107163028-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022195499-A1 |
| priorityDate |
2014-07-16^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |