http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-991485-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6469180d9cbfca6c2fb27722d8df4a67 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-14 |
| filingDate | 1962-09-14^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a586e7238488313d3b953ff581ba58f5 |
| publicationDate | 1965-05-12^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-991485-A |
| titleOfInvention | Phenyl-indolyl-aminoalkanols |
| abstract | The invention comprises compounds of the formula <FORM:0991485/C2/1> where R1 is hydrogen, halogen or alkoxy, R2 is hydrogen, alkyl or aralkyl, R3 is hydrogen or alkyl, R4 is hydrogen, halogen, alkoxy, alkyl or trifluoromethyl, A is C3-6 alkylene and B is alkylamino or dialkylamino, or a saturated mononuclear 5- or 6-membered heterocyclic group attached via a nitrogen atom; acid addition salts thereof; and their preparations by reacting an appropriate indolyl phenyl ketone with a compound BAMgX (where X is halogen) and hydrolysing the product. Indol-3-yl o-tolyl ketone and p-tolyl ketone are prepared from indole and o- and p-toluyl chloride respectively, in the presence of ethyl magnesium iodide. Indol-3-yl m-tolyl ketone is prepared from indole, m-toluylic acid dimethylamide and POCl3. The compounds of the invention and their non-toxic acid addition salts possess antiallergic and sedative properties, and are employed in pharmaceutical preparations with a pharmacologically acceptable carrier. They may be administered orally, e.g. as tablets, pills, capsules, suspensions, emulsions, syrups or elixirs, or parenterally. |
| priorityDate | 1962-09-14^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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