| abstract |
The present invention provides a compound of formula (I), or a possible filler, stereoisomer or optically active form thereof, or a pharmaceutically acceptable salt thereof, wherein R1 and R2 are, interchangeably or differently hydrogen, R2, optionally substituted alkyl, or alkyl, or acyl. a 3-8 membered ring former; R3 and R4 are, optionally or differently, optionally substituted alkyl radicals, or R3 and R4 form a cyclic or quenched ring system; R5 is hydrogen, alkyl, acyl or alkoxycarbonyl; X1, X2, X3 and X4 are, as the case may be, hydrogen or halogen, nitro, cyano, hydroxy, optionally substituted alkyl, alkenyl, alkynyl, optionally substituted alkoxy, optionally substituted alkyl, optionally in each case a phenyl tube substituted with a single halogen atom and / or an alkyl moiety, -NX5X6 or -C (O) X7, of which X5 and X6 are in each case different or different hydrogen, optionally substituted alkyl, acyl, or optionally substituted alkyl, acyl, and X6 together may form a 3-8 membered ring; X7 is hydrogen, hydroxy, optionally substituted alkyl, optionally substituted alkoxy, or -NX8X9; wherein X8 and X9 are, optionally or differently, hydrogen, optionally substituted alkyl; or X8 and X9 together may form a ring of 3 to 8 carbon atoms; A is an optionally substituted benzene ring or a 5- or 6-membered aromatic heterocycle containing at least one nitrogen gene engine as an optionally substituted and heteroatom; n and m are 0 or 1. The present invention also relates to the preparation of the above compounds, and more particularly to pharmaceutical compositions containing them for the treatment of cerebrovascular and other diseases. ŕ |