| abstract |
The present invention relates to compounds and methods for the preparation of cyclooxygenase-2 mediated diseases, such as compounds and compositions for the treatment of inflammatory and inflammatory disorders, within the scope of anti-inflammatory drugs. According to the invention, compounds of formula (I ') are useful in the treatment of diseases mediated by the cyclooxygenase-2 enzyme, wherein Ra, Rh and Rc are typically hydride, C 1-3 alkyl, phenyl-C 1-3 alkyl, wherein R is carboxyl, amino -Carbonyl, (C 1 -C 6) alkylsulfonylaminocarbonyl or (C 1 -C 6) alkoxycarbonyl; wherein R <is a hydride group, phenyl group, thienyl group, C2-C6 alkynyl group or C2-C6 alkenyl group; wherein R 1 is C 1-3 perfluoroalkyl, chloro, C 1-6 alkylthio, C 1-6 alkoxy, nitro, cyano or cyano-C 1-3 alkyl; wherein R 2 is hydride, halo, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, halo-C 2-6 alkynyl, aryl-C 1-3 alkyl, aryl-C 2-6 alkynyl, aryl-2-6 C 1 -C 6 alkenyl, C 1 -C 6 alkoxy, methylenedioxy, C 1 -C 6 alkylthio, C 1 -C 6 alkylsulfinyl, aryloxy, arylthio, arylsulfinyl, heteroaryloxy, C 1 -C 6 alkoxy-C 1 -C 6 alkyl, aryl-C 1 -C 6 -alkyl C 1-6 alkyloxy, aryl-C 1-6 alkoxy-C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 haloalkoxy, C 1-6 haloalkylthio, C 1-6 haloalkylsulfinyl, C 1-6 haloalkyl C 3 -C 5 haloalkyl (C 1-3 hydroxyalkyl), C 1-6 hydroxyalkyl, hydroxyimino-C 1-6 alkyl, C 1-6 alkylamino, arylamino, arylC 1-6 alkylamino, hex teroarylamino, heteroaryl-C 1-6 alkylamino, nitro, cyano, amino, aminosulfonyl, C 1-6 alkylaminosulfonyl, arylaminosulfonyl, heteroarylaminosulfonyl, aryl-C 1-6 alkylaminosulfonyl, heteroaryl-1-6 carbonyl, heteroaryl-1-6 carbonyl, heteroaryl-1-6 carbonyl; sulfonyl, C 1-6 alkylsulfonyl, aryl-C 1-6 alkylsulfonyl, optionally substituted aryl, optionally substituted heteroaryl, aryl-C 1-6 alkylcarbonyl, heteroaryl-C 1-6 alkylcarbonyl, heteroarylcarbonyl, arylcarbonyl, aminocarbonyl one or more radicals independently selected from alkoxycarbonyl, formyl, C 1-6 haloalkylcarbunyl, and C 1-6 alkylcarbonyl radicals, and wherein ring A is ring member A1, A2, A3 and A4; |