| abstract |
The present invention relates to gestagenic and androgenic compounds of formula (I) wherein R1 and R2 are hydrogen, halogen or alkyl, or R1 and R2 together with the carbon atom in the carbon chain, R3 is optionally partially or fully fluoroalkyl. bicyclic aromatic group substituted by the following atoms and / or groups: halogen, alkyl, -CR5 = CR6R7, where R5, R6 and R7 are hydrogen or alkyl, hydroxy, acyl, carbalkoxyalkyl, cyanoalkyl , allyl, 2-propynyl, alkoxyalkyl, fluoroalkyl, cyano, nitro, alkoxy, alkylthio, mono- or disubstituted amino or fluoroalkyl, -COOR4, wherein: R4 is alkyl, -CR5 = CR6R7, where R5, R6 and R7 are hydrogen, halogen, aryl or alkyl, -C, CR5, where R5 is hydrogen or alkyl, fluoroalkyl, carbonyl; Y is methylene, Ar is a different carbocyclic or heterocyclic group, and when B is methylene, the compounds of general formula (I) are physiologically acceptable salts with acids. Another aspect of the invention is a method for the preparation of fentanyl compounds, as well as pharmaceutical compositions effective in the treatment of drug disorders, contraception, male fertility, and hormone replacement therapy. HE |