http://rdf.ncbi.nlm.nih.gov/pubchem/patent/HU-0300212-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1bde28565d28f037e78bf4a67776ee24 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-87 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-343 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-343 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-87 |
| filingDate | 2001-02-22^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_849c1a746c738ee95be511abde8cb9b6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8471d45fa9c1955864c3972769c6a753 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_02a02a19757b09826fc9edcc59ae2d0d |
| publicationDate | 2003-06-28^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | HU-0300212-A2 |
| titleOfInvention | Process for the preparation of citalopram |
| abstract | The present invention relates to a process for the preparation of a well-known antidepressant citalopram, i. E. In its invention, the compound of formula (I) is reacted with a compound of formula (II) wherein X is a leaving group, and R is -CH2-O-Pg, -CH2-NPg1Pg2, -CH2-NMePg1, -CO- N (CH3) 2, -CH (OR1) (OR2), -C (OR4) (OR5) (OR6), -COOR3, -CH2-CO-NH2, -CH = CHR7, or -CO-NHR8; in which groups Pg is a protecting group for the alcohol group, Pg1 and Pg2 are for the amino group, R1 and R2 are independently selected from the group consisting of alkyl, alkenyl, alkynyl, or optionally alkyl substituted with alkyl, or R1 and R2 together form a chain containing from 2 to 4 carbon atoms, R3; , R4, R5, R6 and R7 are each independently aryl or aralkyl substituted with alkyl, alkenyl, alkynyl or optionally alkyl, and R8 is hydrogen or methyl; the R group of a compound of the formula wherein R is as defined above is converted to a dimethylaminomethyl group and finally citalopram is isolated as a free base or as a pharmaceutically acceptable salt. HE |
| priorityDate | 2000-02-24^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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