| abstract |
Aromatic or heterocyclic oxazapines (or thiazepines) of formula (I) and their salts are prepared by, (a) the halogenation of the cpd. of formula (Nb) to produce the cpd. of formula (III) or its free base, (b) fusing the produced cpds. to produce the cpds. of formula (IIa), (C) reacting the produced halogen cpds. with the cpd. of formula ZH. The new cpds. of formula (I) are useful as antihistaminic agents. |