http://rdf.ncbi.nlm.nih.gov/pubchem/patent/IE-38377-L
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4acae202b6a15394281949545e70d2f6 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-403 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J73-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-66 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-58 |
| filingDate | 1973-10-12^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1974-04-13^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | IE-38377-L |
| titleOfInvention | Maleopimarimide derivatives |
| abstract | 1417996 Maleopimarimide derivatives ROUSSEL LABORATORIES Ltd 28 Sept 1973 [13 Oct 1972] 47437/72 Heading C2C The invention comprises compounds of formula wherein NR<SP>1</SP>R<SP>2</SP> is an optionally substituted heterocyclic radical and Y is H, NH 2 , acyl, or alkyl (optionally substituted by OCOCONR<SP>1</SP>R<SP>2</SP>, or by one or more of OH, dialkylamino or alkoxycarbonyl), each alkyl or acyl group containing up to 5 C atoms. In examples, these compounds are prepared by reacting (1) the corresponding cyclic anhydride (made from the cyclic anhydride/acid chloride (A) and HNR<SP>1</SP>R<SP>2</SP>) with YNH 2 ; (2) the corresponding cyclic imide/ acid chloride (B) with HNR<SP>1</SP>R<SP>2</SP>; (3) the analogous compound where Y=K, with a Y-halide; or (4) (for the compound where Y is OCOCONR<SP>1</SP>R<SP>2</SP>-substituted alkyl) the acid chloride precursor of the analogous compound where Y is OCOCOCl, with HNR<SP>1</SP>R<SP>2</SP>. Intermediates otherwise prepared are the parent acids of the chlorides (A), (B). Therapeutic compositions for oral, parenteral or rectal administration comprise compounds of the above formula, which have hepatoprotective activity.n[GB1417996A] |
| priorityDate | 1972-10-13^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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