| abstract |
Compounds of general formula I or II: <IMAGE> are disclosed, wherein <IMAGE> represents tertiary amine <IMAGE> an unsaturated amine and R2, R3 and R4 (which may be the same or different, but at least two of them must be other than H and together they must contain at least five C-atoms) each represents hydrogen, C1-C8 alkyl or alkoxy, cycloalkyl cycloalkenyl, alkoxyalkyl, acyloxyalkyl, haloalkyl or carboxyalkyl each having up to 8 C atoms, alkenylphenyl having unto 8 C-atoms in the alkenyl moiety, aryl (optionally substituted by halogen, C1-C4 alkoxy, acyloxy, nitro, carboxyl or carboethoxy), -CH2, -CH2OCOR1 (wherein R1 is as defined below or -CH2ONO2), -OH, halogen, -OCOR1 (wherein R1 is as defined below) or - ONO2; or R2 is as hereinbefore defined and R3, R4 and the carbon atoms to which they are attached form a cyclo-alkyl group having up to 8 carbon atoms, or the groups represented by R2, R3 and R4 and the carbon atom to which they are attached form a fused polycarbocylic ring or a polyheterocyclic ring; and R1 is as defined by R2, R3 or R4; X is -O- or -S- and Y is halogen or another anion. The compounds possess anticholinergic anti- secretory activity, while exhibiting low toxicity following therapeutic application.n[GB2010270A] |