| abstract |
Intermediates of the structural formula III or Va having an asymmetric center as indicated by an asterisk (*) and being substantially free of its opposite enantiomeric form: wherein: Z represents O or NOP<1> P<1> is H, alkyl, benzyl, substituted benzyl, alkoxy-substitued phenyl, alkyloxyalkyl, alkylthioalkyl or R'R"R'"silyl. R<1> and R<2> may be the same or different and each independently represents H, alkyl, phenyl, substituted phenyl or R<1> and R<2> together with the carbon to which they are attached represent the group Y is O, S(O)p or (CRR), and processes for making chemically pure, enantiomeric antifungal compounds using a threonine derived asymmetric chemical synthesis. |