abstract |
Crystalline monohydrate (I) of tiotropium bromide ((1alpha,2beta,4beta,5alpha,7beta)-7-(2-hydroxy-2,2-di(2-thienyl)acetoxy)-9,9-dimethyl-3-oxa-9-azonia-tricyclo(3.3.1.02.4)nonane bromide) is new. An Independent claim is also included for the preparation of (I). |