| abstract |
(57) [Summary] Condensed pyrazine compound represented by the general formula (I) or a non-toxic salt thereof, and a drug containing the same as an active ingredient (wherein R 1 and R 2 are H, alkyl, alkoxy, , -COOR 14 group or the like; J is N, C-R 7; represents G is (substituted) alkyl group, a carbocyclic ring, etc.); E is a single bond, O, S or the like.. Embedded image [Effect] The compound represented by the general formula (I) has an inhibitory effect on the expression of adhesion molecules, and is useful for various inflammatory diseases, rheumatoid arthritis, allergy, bronchial asthma, atopic dermatitis, psoriasis, ischemia-reperfusion injury. Suppression, nephritis, hepatitis, multiple sclerosis, ulcerative colitis, acute respiratory distress syndrome, suppression of transplant rejection, sepsis, diabetes, autoimmune disease, cancer metastasis, It is useful for the prevention and treatment of arteriosclerosis and AIDS. |