| abstract |
(57) [Summary] [Problem] To provide a therapeutic agent for heart failure. SOLUTION: Formula (I) (In the formula, R 1 represents a hydrogen atom, a nitro group, a cyano group, a C 1-6 alkylcarbonylamino group, etc., and R 2 and R 3 each independently represent a C 1-6 alkyl group, etc. R 4 represents a hydroxyl group or a C 1-6 alkylcarbonyloxy group, or together with R 5 represents a bond or an epoxy group; R 5 represents a hydrogen atom, R 6 represents NR 7 R 8 or the like, and n Represents an integer of 0 to 4, and X represents C = O, CH 2 , SO 2 or N R 16 means Y is NR 17 when X is C = O, CH 2 or SO 2 And when X is NR 16 , C = O, and Z is N R 17 does not exist; when Y is C = O, it means NR 18 ; W means an aromatic group or a lactam ring; ] A therapeutic agent for heart failure comprising an indane derivative represented by the formula (1) or a salt thereof as an active ingredient. |