| abstract |
(57) [Summary] General formula: [Wherein X 1 , X 2 , X 3 and X 4 are each independently a carbon atom or a nitrogen atom, n is 0 or 1; A is selected from an oxygen atom or a carbonyl group: R 1 and R 2 is each independently a hydrogen atom; an aromatic ring which may be substituted; an aromatic hetero ring which may be substituted having one or more hetero atoms; one or more which may be substituted by an alkyl chain A saturated ring having a hetero atom; a nitrogen which may be substituted, an aromatic ring which may be substituted, or an aromatic hetero ring which may be substituted, which may have one or more hetero atoms, be terminated. R3 is any one of a chain having 1 to 4 carbon atoms; R3 is a hydrogen atom, a halogen atom, a C1-5 alkyl group, or two groups each independently consisting of a hydrogen atom or a C1-5 alkyl group ( Carbonyl group And R 4 is a hydrogen atom, a halogen atom, a C 1-5 alkyl group, or an oxygen-containing derivative which may be substituted]. Therapeutic use of bicyclic derivatives and their pharmaceutically acceptable salts, except for 6-phenylamino-5,8-quinolinedione and 2-N-acetylamino-1,4-naphthoquinone. |