| abstract |
(57) [Summary]nThe present invention relates to novel homologues of camptothecin, in particular the compound 8-ethyl-8,9-dihydro-8-hydroxy-1-benzyl-2H, 10H, 12H- [1,3] oxazino [5, 6-f] oxepino [3 ', 4': 6,7] indolizino [1,2-b] quinoline-10,13 (15H) -dione; 5-ethyl-9,10-difluoro-4,5-dihydro -5- (2-amino-1-oxoethoxy) -1H-oxepino [3 ', 4': 6,7] indolizino [1,2-b] quinoline-3,15 (4H, 13H) -dione; 5 -Ethyl-9,10-difluoro-4,5-dihydro-5- (2-amino-1-oxopropoxy) -1H-oxepino [3 ', 4': 6,7] indolizino [1,2-b] Quinoline-3,15 (4H, 13H) -dione; The present invention also relates to a process for preparing these compounds, their pharmaceutical application, pharmaceutical compositions containing these compounds and their use in the preparation of antitumor, antiviral and antiparasitic medicaments. |