abstract |
(57) [Summary]nThe present invention discloses a novel method for conjugating macromolecules to other molecular entities. In particular, the invention shows a method for conjugate or derivatization of oligonucleotides and proteins by cycloaddition reactions, such as a Diels-Alder reaction or a 1,3-dipolar cycloaddition reaction. The present invention includes novel bioconjugated polymers that can be produced by the method of the present invention. |