| abstract |
(57) [Summary]nGenetic engineering is performed on secretory gland cells, particularly pancreatic, liver, and salivary gland cells, to functionally incorporate a gene that expresses a protein that has a desired therapeutic effect on a mammalian subject. The expressed protein is secreted directly into the bloodstream, resulting in a therapeutically effective level of the protein and the treatment of patients in need of the protein. Transformed secretory cells provide a long-term or short-term treatment for diseases involving the deficiency of certain proteins, or in response to treatment with overexpression of proteins. |