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classificationCPCAdditional http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-52
classificationIPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-38
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filingDate 2000-07-13^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6e4dd64674280bb31470206bdb71825f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7f4058e44164104d7c295dfd6b0662c7
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publicationDate 2002-01-29^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-2002030078-A
titleOfInvention Method for producing amidothiazole derivative
abstract (57) [Problem] To provide a method for easily obtaining an amide thiazole derivative ester compound useful as an intermediate of a cephalosporin antibiotic with high purity. SOLUTION: An N-protected amino acid compound such as tert-butoxycarbonyl-L-alanine and 2 -(2-aminothiazol-4-yl) -2- (Z)- By condensing with an aminothiazole derivative ester compound such as ethyl methoxyiminoacetate, 2- (2-tert- Butoxycarbonyl-L-alanylaminothiazole- In a method for producing an amidethiazole derivative ester compound such as ethyl 4-yl) -2- (Z) -methoxyiminoacetate, a halogenoformate compound such as isobutylchloroformate and a thiocyanate such as N-methylmorpholine are used as a condensing agent. A secondary amine compound is used.
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