| abstract |
(57) [Summary] [Problem] To elucidate the factors that regulate the interaction between AGE and its receptors that occur in vivo with diabetes and aging, and to investigate various biological activities, physiological phenomena, Research and development of diseases. SOLUTION: RAGE has multiple molecular species, Among them, soluble RAGE has an activity that controls the interaction between AGE and transmembrane RAGE. Not only can this soluble RAGE be measured using the nucleic acid that encodes it, but also research into various physiological phenomena, biological activities, diseases, etc. involving the interaction between AGE and RAGE, It is also useful for research and development of useful medicines. |