abstract |
(57) Abstract The present invention provides an isolated nucleic acid molecule encoding a novel ABC transporter family member, designated ABCB12 transporter nucleic acid molecule. The present invention also provides an antisense nucleic acid molecule, a recombinant expression vector containing the ABCB12 transporter nucleic acid molecule, a host cell into which the expression vector has been introduced, and a non-human transgenic animal into which the ABCB12 transporter gene has been introduced or disrupted. I do. The invention further provides screening assays for isolated ABCB12 transporter proteins, fusion proteins, antigenic peptides, anti-ABCB12 transporter antibodies, and ABCB12 transporter modulators. Diagnostic and therapeutic methods using the compositions of the present invention are also provided. |