| abstract |
(57) Summary A compound having the structural formula (I) or a pharmaceutically acceptable salt thereof is disclosed. Specifically, the present invention relates to substituted 5-amino-pyrazolo- [4,3-e] -1,2,4-triazolo [1,5-c] pyrimidine adenosine A 2a receptor antagonists, central nervous system It relates to the use of these compounds in the treatment of diseases, in particular Parkinson's disease, and to pharmaceutical compositions comprising these compounds. The present invention is also a method of treating central nervous system diseases such as depression, cognitive and neurodegenerative diseases such as Parkinson's disease, senile dementia or psychosis of organism origin, and seizures, such as Administering a compound of formula I to a mammal in need of treatment. |