| abstract |
A triazaspiro [5.5] undecane derivative represented by the general formula (I), a quaternary ammonium salt thereof, an N-oxide thereof, a non-toxic salt thereof, and a drug containing the same as an active ingredient (formula (I)) Wherein R 1 is a group represented by formula (II) or (III); R 2 is alkyl, alkynyl or the like; R 3 and R 4 are H, (substituted) alkyl or the like, or R 3 and R 4 are a group represented by the formula (IV) ); R 5 represents H, alkyl.) Embedded image [Effect] Since the compound represented by the general formula (I) controls the action of a chemokine / chemokine receptor, various inflammatory diseases, asthma, atopic dermatitis, urticaria, allergic disease, nephritis, nephropathy, hepatitis , Arthritis, rheumatoid arthritis and the like. [Selection diagram] None |