| abstract |
A compound or a pharmaceutically acceptable salt of the compound for inhibiting the action of phosphodiesterase (PDE) type IV in a mammal or inhibiting the production of tumor necrosis factor (TNF) in a mammal. And a method of using the compound or a pharmaceutically acceptable salt of the compound. Further, the present invention provides an intermediate useful for producing the compound. [Solution] [R is a phenyl group; R1 is C1-C9 alkyl; R2 is phenyl, naphthyl, pyrrolyl, furanyl, thienyl, oxazolyl, pyridinyl, pyrimidinyl, pyridazinyl, quinolinyl, isoquinolinyl, 5,6,7,8-tetrahydroquinoyl Nolinyl or 5,6,7,8-tetrahydroisoquinolinyl], or a pharmaceutically acceptable salt of the compound. [Selection diagram] None |