| abstract |
The present invention provides a compound of formula (I) or a pharmaceutically acceptable derivative thereof, wherein A, B, R a , R 1 , R 2 , R 3 and R 4 are as defined herein. As described in. These compounds are inhibitors of protein kinases, particularly JNK kinases, which are mammalian protein kinases involved in cell proliferation, cell death and response to extracellular stimuli; Lck and Src kinases. The invention also relates to a method for producing these inhibitors. The present invention also provides pharmaceutical compositions containing the inhibitors of the present invention and methods of using these compositions in the treatment and prevention of various disorders. |