| abstract |
PROBLEM TO BE SOLVED: To inhibit ABC transporter to overcome multidrug resistance to anticancer drug by amplification / expression of MDR1 gene, which is the biggest problem in cancer chemotherapy, or to overcome drug resistance of antifungal drug in mycosis The purpose is to provide an agent. An ABC transporter inhibitor containing enniatins as an active ingredient. The ABC transporter inhibitor of the present invention inhibits the transport, excretion of drugs, particularly anticancer drugs and antifungal drugs from the inside of the cell to the outside of the cell, and thus prevents, suppresses or prevents the acquisition of resistance to various drugs. Useful for. [Selection figure] None |