| abstract |
A novel protein, a non-genomic activity modulator of nuclear receptors (MNAR), which interacts with estrogen receptor α (ERα), estrogen receptor β (ERβ), and other nuclear receptors Was discovered and characterized. The MNAR-ER complex interacts with and stimulates the enzymatic activity of tyrosine kinases such as p60 c-src (cSrc) and p56 lck (LCK) in vitro and in vivo. MNAR also stimulates ER transcriptional activity. The invention also relates to nucleic acids, antisense, recombinant expression of nucleic acids, and host cells, compositions, and assays that utilize the nucleic acids and proteins of the invention. |