| abstract |
PROBLEM TO BE SOLVED: To provide a novel nucleic acid molecule useful for regulation of gene expression. (A) a nucleotide sequence having 14-24 nucleotides complementary to a nucleotide sequence of a target RNA or a part thereof; (B) 5′-cap, 3′-cap, or both 5′-cap and 3′-cap on one strand of a double-stranded nucleic acid molecule; and (c) modified nucleotides and modified A mixture of non-nucleotides, where the modified nucleotides are 2'-fluoro, 2'-O-methyl, 2'H or combinations thereof, and the unmodified nucleotides are ribonucleotides, Chemically synthesized double stranded nucleic acid molecules comprising are disclosed. [Selection figure] None |