| abstract |
Novel pyrrole-based compounds, compositions and methods of inhibiting the activity of glycogen synthase kinase (GKS3) in vitro and treating GSK3-mediated disorders in vivo are provided. The methods, compounds and compositions of the present invention may be used alone or in combination with other pharmacologically active agents for disorders mediated by GSK3 activity (eg, diabetes, Alzheimer's disease and other neurodegenerative disorders, It can be used in the treatment of diabetes, atherosclerotic cardiovascular disorders, essential hypertension, polycystic ovary syndrome, syndrome X, ischemia, traumatic brain injury, bipolar disorder, immunodeficiency or cancer)). |