| abstract |
【task to solve】 To develop new substances that are effective in treating neurological conditions. [Solution] The present invention relates to methods for treating, ameliorating and / or preventing neurological conditions, particularly neurodegenerative conditions such as neurodegenerative amyloidosis. The method includes administering an effective amount of a compound of formula (I) to a subject in need thereof. The above neurodegenerative conditions include sporadic or familial Alzheimer's disease, amyotrophic lateral sclerosis, cataract, Parkinson's disease, Creutzfeldt-Jakob disease and its new species related to mad cow disease, Huntington's disease, Levy small It may be somatic dementia, multiple system atrophy, Hallelfolden-Spatz disease, diffuse Lewy body disease, lethal familial insomnia, Gerstmann-Stroisler-Scheinker disease, or Dutch hereditary amyloid cerebral hemorrhage preferable. The present invention also provides compounds of formula (II) and methods for their preparation. |