| abstract |
PROBLEM TO BE SOLVED: To provide a novel bicycloester derivative having excellent DPP-IV inhibitory activity or a pharmacologically acceptable salt thereof, and a prophylactic and / or therapeutic agent for a disease involving DPP-IV containing them as an active ingredient provide. [Solution] General formula (1) [Chemical 1] Or a pharmacologically acceptable salt thereof (specific example: (2S, 4S) -4-fluoro-1-[[N-[(5-methyl-2-oxo-1,3 -Dioxolen-4-ylmethyl) oxycarbonylbicyclo [2.2.2] oct-1-yl] amino] acetyl] pyrrolidine-2-carbonitrile). [Selection figure] None |