| abstract |
A multilamellar liposome for percutaneous absorption and a method for producing the same are disclosed. This multilamellar liposome is manufactured using a mixture of oil phase components including squalene, sterol, ceramide, neutral lipid or oil, fatty acid and lecithin, and has a particle size of 200 to 5000 nm and contains a bioactive active ingredient therein. Can be collected. The multilamellar liposomes provided by the present invention have a larger amount of bioactive active ingredients than monolamellar liposomes, the structurally encapsulated active ingredients are stable, and are generally available rather than high-pressure homogenizers. Can be manufactured using a simple homomixer, the manufacturing process is simple and economical, and the size is larger than the gap between skin keratinocytes. Since it can be released from the tension to surrounding cells and penetrate into the dermis layer, it can be used to promote percutaneous absorption of physiologically active ingredients. |