| abstract |
The present invention relates to certain trisubstituted aryl and heteroaryl derivatives of formula (I), which are modulators of metabolism. Accordingly, the compounds of the present invention are useful in the prevention or treatment of metabolic disorders and their complications (eg, diabetes and obesity). One aspect of the present invention pertains to pharmaceutical compositions comprising at least one compound of the present invention and a pharmaceutically acceptable carrier. One aspect of the present invention relates to a method of reducing food intake of an individual, said method comprising subjecting said individual in need thereof to a compound of the present invention or a pharmaceutically acceptable salt, hydrate or solvate thereof. Administering a therapeutically effective amount of the product. One aspect of the invention relates to a method of inducing satiety in an individual. One aspect of the present invention relates to a method of controlling or reducing an individual's weight gain. One aspect of the invention pertains to a method of modulating a RUP3 receptor in an individual, the method comprising contacting the receptor with a compound of the invention. |