http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2008137895-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_362d7df142655613551c77e74b6366de |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B61-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-04 |
| filingDate | 2006-11-20^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e1c2c3fd8d4dc1d63eb8b3a408ab5b72 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3dcafb2c94a5ef975b0bd66304bfe44e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_61198eacf8cf99c19452f1b68acd6a03 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_02e36c6702048c99c98796735c89a8a2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d1764bacb580493443e9feef7cbdc954 |
| publicationDate | 2008-06-19^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2008137895-A |
| titleOfInvention | Method for preparing S-pantoprazole |
| abstract | The present invention provides an improved process for the preparation of S-pantoprazole. 5-Difluoromethoxy-1-benzimidazole-2-thiol is reacted with 2-chloromethyl-3,4-dimethoxypyridine in the presence of a phase transfer catalyst and a base in a solvent to give 5- (difluoro Methoxy) -2-(((3,4-dimethoxypyrrolidin-2-yl) methyl) thio) -1H-benzimidazole is obtained. This is stereoselectively oxidized in situ in the presence of a stereoselective reaction reagent, oxidant and base to give S-pantoprazole, which is treated with an alkaline solution as necessary to give pure S- An improved method for the preparation of S-pantoprazole to obtain pantoprazole. S-pantoprazole is reacted with a base in a solvent to obtain a pharmaceutically acceptable stable salt of S-pantoprazole or a hydrate thereof. [Selection figure] None |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014092188-A1 |
| priorityDate | 2006-11-20^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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