| abstract |
To improve an adenovirus system for virus-induced oncolysis, increase the success rate of tumor treatment, and to provide an adenovirus system for virus-induced oncolysis that is effective against wild-type p53 tumors. A nucleic acid comprising an adenovirus nucleic acid, further comprising a nucleic acid sequence encoding YB-1, is provided and used for the treatment or prevention of tumor diseases. [Selection] Figure 2 |