http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2008502592-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4721 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-02 |
| filingDate | 2005-03-10^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2008-01-31^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2008502592-A |
| titleOfInvention | Modified annexin protein and method for preventing thrombosis |
| abstract | A modified annexin protein, preferably annexin V, is used to prevent thrombosis without increasing bleeding. Annexin binds to phosphatidylserine on the outer surface of the cell membrane, thereby preventing the binding of the prothrombinase complex required for thrombus formation. However, annexins do not affect the platelet aggregation required for hemostasis. The modified annexin molecule can also be an annexin homodimer, an annexin molecule coupled to one or more polyethylene glycol chains, or an annexin molecule coupled to another protein. By increasing the molecular weight of the annexin, a modified annexin is made and remains in circulation for a time sufficient to provide a sustained therapeutic effect. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2020040951-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11472837-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11773134-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2021176856-A |
| priorityDate | 2004-03-11^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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