| abstract |
Tie1 and Tie2 are receptor tyrosine kinase proteins that include a transmembrane domain. Tie1 and Tie2 are present on endothelial cells. The present disclosure describes agents such as antibodies that bind to Tie1, Tie2, and Ang, including those that inhibit endothelial cell activity and angiogenesis. The drug can be used to treat angiogenesis-related disorders. In one aspect, the invention features a method of modulating Tie complex formation or interaction between Tie complex components in a subject. |