| abstract |
Disease states associated with angiogenesis and / or increased vascular permeability (eg, cancer, diabetes, psoriasis, rheumatoid arthritis, Kaposi's sarcoma, hemangioma, acute and chronic kidney injury, atheroma, arterial restenosis, Providing compounds that significantly inhibit the effects of VEGF as valuable properties in the treatment of autoimmune diseases, acute inflammation due to retinal vascular proliferation and ocular diseases. The present invention relates to quinazoline derivatives of formula (I) and salts thereof; processes for their preparation; and pharmaceutical compositions containing compounds of formula (I) as active ingredients and pharmaceutically acceptable salts thereof Related to things. The compounds of formula (I) and their pharmaceutically acceptable salts inhibit the effects of VEGF as a valuable property in the treatment of many disease states including cancer and rheumatoid arthritis. [Selection figure] None |