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filingDate 2006-07-19^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2009-01-29^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-2009502790-A
titleOfInvention CFTR LPA2 receptor agonist inhibitor
abstract Disclosed are methods and compositions for treating or preventing diarrhea. The method includes administering to the individual a therapeutically effective amount of an LPA 2 receptor agonist to treat or prevent diarrhea. At least one LPA 2 receptor agonist in an amount effective to inhibit the formation of a macromolecular complex between LPA 2 receptor, CFTR, and Na + / H + exchange regulator 2 (NHERF-2) Also disclosed are methods of inhibiting CFTR activation by administration.
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