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publicationDate 2009-05-21^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-2009520196-A
titleOfInvention Screening compounds for activity in the regulation of chloride transport
abstract A method for screening a test compound for activity in modulating the action of the chloride channel ClC-7, either directly or by modulating the intracellular localization of Ostm1, provides that the test compound binds to ClC-7 by Ostm1. Measuring whether it inhibits. Compounds active in screening are candidates for use in treating bone resorption conditions such as osteoporosis by modulating osteoclast activity.
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