| abstract |
The present invention relates to a new class of fluorinated arylamide derivatives. The present compounds can be used to treat cancer. The fluorinated arylamide derivatives are also capable of inhibiting histone deacetylase, selectively inducing terminal differentiation of new cells, cell growth arrest, and / or apoptosis, thereby Suitable for use in inhibiting proliferation. Accordingly, the compounds of the present invention are useful in treating patients with tumors characterized by neoplastic cell proliferation. The compounds of the present invention are also used in the prevention and treatment of TRX-mediated diseases, such as autoimmune diseases, allergic diseases, and inflammatory diseases, and in the central nervous system (CNS), such as neurodegenerative diseases. It may also be useful in the prevention and / or treatment of disease. The present invention further provides pharmaceutical compositions comprising hydroxamic acid derivatives, and a safe dosing regimen of these pharmaceutical compositions to produce a followable and therapeutically effective amount of the hydroxamic acid derivative in vivo. provide. |