| abstract |
The present invention relates to a method for diagnosing neonatal diabetes, congenital hypothyroidism, and congenital glaucoma, and detecting embryonic stem cells (ES cells) or human somatic stem cells, including detecting the presence of mutations in the GLIS3 gene. By culturing human pluripotent or pluripotent cells in a medium containing an effective amount of GLIS3 to induce differentiation of the cells into functional pancreatic β cells that produce insulin, functional pancreas The present invention relates to a method for preparing β cells. The present invention further relates to a pharmaceutical composition comprising GLIS3 as an active ingredient. |