| abstract |
The present invention provides novel substituted tetracycline compounds useful for treating many tetracycline compound responsive states such as bacterial infections and neoplasms. A compound of the following formula: Wherein X is CH 2, a CH- alkyl etc., R 2, R 2 ', and R 3, R 10, R 11 , R 12 is hydrogen or the like, the R 4 is dimethylamino group, R 5 is hydrogen or the like R 7 represents hydrogen, a carboxyl group, an amino group, a cyano group, an optionally substituted phenyl group or a heterocyclic group, R 8 represents hydrogen or the like, R 9 represents hydrogen, an alkyl group, an amino group, or the like. To express. [Selection figure] None |