| abstract |
A system for electrokinetically delivering methotrexate includes at least one applicator with a plurality of non-conductive microneedles that are supported on a non-conductive surface of the applicator. The opposite surface is formed from a conductive material and contacts the active electrode. The applicator includes a matrix containing a drug, such as methotrexate or its carrier, between opposing surfaces. An electrical circuit through the power source, active electrode, methotrexate or its conductive carrier, target administration site, individual body, ground electrode, with the applicator in contact with the individual's skin and the microneedle penetrating the skin Is completed, the drug is electrokinetically moved to the target administration site via the non-conductive microneedle. |